Over 25 years of research supports the oral use of GR-1 and RC-14 to colonize and promote healthy vaginal and urinary tract health.* A special manufacturing process protects the probiotic strains in Fem-Dophilus from stomach acid and enhances probiotic bacterial survival to the lower intestine.* Fem-Dophilus does not require refrigeration and can be stored at room temperature. Refrigeration will, however, extend the shelf life. Avoid temperatures above 77F (25C). GR-1®/RC-14 and VAGINAL FLORA (also called microbiota) In one of the randomized clinical trials, 75% of women in the GR-1/RC-14 probiotic group experienced significant improvement in vaginal flora composition, while only 34% of women in the placebo (non-probiotic) group experienced similar improvement. RC-14 and GR-1 are registered trademarks of Chr. Hansen A/S.